RAF Typhoon FGR4s have operated alongside French aircraft in a joint strike on an underground arms cache in Syria used by the Daesh militant organization, according to the UK's MoD.
The site, identified by surveillance, was thought to be storing arms and explosives, the announcement noted, and was positioned in mountains just north of Palmyra in Syria's central region.
"The RAF jets employed Paveway IV guided bombs to target a number of approach shafts providing entry to the depot... initial indications are that the target was engaged successfully," the ministry announced.
There was no sign of any harm to civilians in the operation on Saturday evening and each participating jet made a safe return, the MoD added.
The Typhoon fighters were supported by a Voyager refuelling tanker.
Daesh - alternatively referred to as the so-called Islamic State - established extremist governance over large swathes of both Syria and Iraq before its territorial defeat in 2019.
"This operation shows British leadership, and resolve to operate in unison with our allies, to eliminate any resurgence of IS and their violent and radical beliefs in the region," the British Defence Secretary the Defence Secretary remarked.
British military aircraft have performed surveillance missions over Syrian airspace to "forestall any efforts to regroup" of the group following its routing at the battle of Baghuz in 2019, the ministry said.
"I must thank all the members of our armed forces involved in this operation for their expertise and their valour," he added. "They were among numerous British personnel on duty over the holidays. This mission, to take out militants who threaten our security, shows how our armed forces are prepared to act, all year round, protecting the UK within its borders and influential overseas."
In December, the US military carried out what it termed a "major assault" against Daesh sites in the country, subsequent to an assault claimed the lives of two American soldiers and a civilian linguist in the Palmyra area.
The U.N. says Islamic State still has between 5,000 and 7,000 fighters in both countries.
